FIGURE 6:

Microtubule growth encounters different barriers through distinct actin architectures. The lamellipodium of T-cells is characterized by a dense network of actin filaments nucleated mostly by Arp2/3 (left side). These branched networks may constitute a physical barrier for MT growth. Formins contain domains that allow them to bind directly to microtubules, allowing them to guide their growth as reported [37], but also potentially allowing them to transmit forces generated by myosin motors associated with formin nucleated filaments (see right). Created with BioRender.com.