FIGURE 9:

Role of Cdc42 GAP proteins in the inheritance of cell polarity and growth patterns. Cdc42 GAP Rga4 displays a distribution with a bias toward the old growing end in wild-type cells (Das et al., 2007; Tatebe et al, 2008). In mutants that lack rga4, Cdc42 GAP Rga6 distribution becomes more asymmetrical in monopolar cells, resulting in daughter cells with different initial volumes and Cdc42 activity. Different levels of active Cdc42 between the two daughter cells lead to divergent growth patterns.