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. 2021 Oct 1;32(20):ar8. doi: 10.1091/mbc.E21-04-0171

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© 2021 van Haastert et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 6: — Potential role of sGC association to the cytoskeleton. (A) Basal cGMP levels in buffer. The interaction between sGC and F-actin is mainly to branched F-actin in pseudopods, which is absent in LatA and in ΔN-sGC, which both show reduced cGMP levels. (B) cAMP-stimulated cGMP levels. During cAMP stimulation the interaction between sGC and F-actin is mainly to parallel F-actin in the cortex, which is absent in LatA and in ΔN-sGC, which both show increased cGMP levels. The data shown are the means and SEM of six determinations; significantly different from wild type at **, P < 0.01 or ***, P < 0.001.