Table 3.

Key proteins involved in both apoptosis and necroptosis.

Protein	Relation of apoptosis and necroptosis	References
RIPK1, RIPK3	In response to TNF, RIPK1 Asp325 is needed for reducing aberrant cell death	[44]
	Inhibiting caspase-8-mediated apoptosis as well as RIPK3-MLKL-dependent necroptosis fully prevents RIPK1-mediated embryonic mortality	[41]
Caspase-8	Caspase-8 is a molecular switch that controls apoptosis and necroptosis, as well as protecting tissues from injury	[42]
	Caspase-8 cleaves itself, other proteins, or both in order to prevent necroptosis	[44]