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The relationship between disease and key proteins.
| Key proteins | Effect in disease | Related diseases | FDA-approved inhibitor (company) | References |
|---|---|---|---|---|
| Caspase-8 | Mediator | Inflammation and disease in rodent malaria | None | [52] |
| RIPK1 | Activation of RIPK1 | Skin diseases, including melanoma, psoriasis, and systemic lupus erythematosus | Sunitinib (Pfizer), Pazopanib (GSK, Novartis) | [53, 54] |
| RIPK3 | Mediator | Sepsis-associated organ injury and chronic lung diseases | Dabrafenib (GSK, Novartis) | [54, 55] |
