TABLE 3.
Cox regression analysis for predicting wound healing among patients referred to specialist treatment at a hospital for chronic leg wounds in Denmark from 2007 to 2012 with 5 years of follow‐up
| Wound healing | ||||||
|---|---|---|---|---|---|---|
| Variable | Person‐years | HR crude (95% CI) | P | HR adjust (95% CI) a | P | |
| Number of subjects | 7431 | |||||
| Age | .001 | >.10 | ||||
| 18 to 39 | 282 | 1 (Ref.) | 1 (Ref.) | |||
| 40 to 59 | 950 | 0.88 (0.80–0.97) | 1.00 (0.91–1.11) | |||
| 60 to 79 | 1940 | 0.84 (0.77–0.92) | 1.01 (0.92–1.10) | |||
| 80+ | 1054 | 0.90 (0.82–0.99) | 1.05 (0.95–1.16) | |||
| Sex | .003 | >.10 | ||||
| Male | 2152 | 1 (Ref.) | 1 (Ref.) | |||
| Female | 2074 | 1.07 (1.02–1.12) | 0.99 (0.94–1.04) | |||
| Cohabitation | >.10 | >.10 | ||||
| Cohabiting | 2014 | 1.01 (0.97–1.06) | 1.00 (0.95–1.05) | |||
| Living alone | 2194 | 1 (Ref.) | 1 (Ref.) | |||
| Educational level | .01 | >.10 | ||||
| Basic | 1684 | 1.08 (1.01–1.16) | 1.04 (0.97–1.11) | |||
| Vocational | 1523 | 1.01 (0.94–1.08) | 1.01 (0.94–1.09) | |||
| Higher | 668 | 1 (Ref.) | 1 (Ref.) | |||
| Place of residence (region) | Year 1 c | <.001 | Year 1 c | <.001 | ||
| Capital | 1828 | 1 (Ref.) | 1 (Ref.) | |||
| Zealand | 769 | 1.02 (0.94–1.10) | 1.05 (0.96–1.14) | |||
| Southern Denmark | 669 | 1.49 (1.39–1.59) | 1.47 (1.37–1.58) | |||
| Central Denmark | 737 | 1.41 (1.32–1.50) | 1.40 (1.30–1.50) | |||
| North Denmark | 206 | 1.90 (1.73–2.08) | 1.88 (1.70–2.07) | |||
| Place of residence (region) | Years 2 to 5 c | <.001 | Years 2 to 5 c | .02 | ||
| Capital | 1 (Ref.) | 1 (Ref.) | ||||
| Zealand | 0.75 (0.60–0.89) | 0.81 (0.65–0.97) | ||||
| Southern Denmark | 1.26 (1.00–1.52) | 1.22 (0.96–1.48) | ||||
| Central Denmark | 1.03 (0.83–1.23) | 1.09 (0.88–1.31) | ||||
| North Denmark | 0.98 (0.62–1.34) | 0.96 (0.59–1.33) | ||||
| Diabetes | <.001 | <.001 | ||||
| No | 3095 | 1 (Ref.) | 1 (Ref.) | |||
| Yes | 1131 | 0.67 (0.63–0.71) | 0.67 (0.63–0.72) | |||
| PAD | Year 1 c | <.001 | Year 1 c | <.001 | ||
| No | 3132 | 1 (Ref.) | 1 (Ref.) | |||
| Yes | 1094 | 0.73 (0.69–0.78) | 0.71 (0.67–0.76) | |||
| PAD | Years 2 to 5 c | .01 | Years 2 to 5 c | .05 | ||
| No | 1 (Ref.) | 1 (Ref.) | ||||
| Yes | 1.24 (1.06–1.42) | 1.19 (1.00–1.37) | ||||
| Charlson index modified b | <.001 | .01 | ||||
| 0 | 2924 | 1 (Ref.) | Ref. | |||
| 1 to 2 | 973 | 0.93 (0.88–0.99) | 0.94 (0.89–1.00) | |||
| ≥3 | 330 | 0.85 (0.77–0.93) | 0.88 (0.80–0.97) | |||
Abbreviation: PAD, peripheral arteria disease.
a
All HR adjusted for the listed covariates.
b
Charlson index excluding diabetes and peripheral arterial disease.
c
Timesplitting, HR the first year and from start of year 2 until end of year 5.