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Clinical trials utilizing Tyrosine Kinase Inhibitors (TKIs) in Chondrosarcoma.
| TKI | STUDY DESIGN/PHASE | # OF PATIENTS | PRIMARY EFFICACY ENDPOINT | REFERENCE |
|---|---|---|---|---|
| Dasatinib | Phase II | n=366 | RR, 6 month PFS | NCT00464620 |
| Imatinib | Interventional | n=35 | Tumor response | NCT00928525 |
| Pazopanib | Phase II | n=70 | ORR | NCT02066285 |
| Regorafinib | Phase II | n=132 | PFS | NCT02389244 |
| Depsipeptide (Romidepsin) | Phase II | n=40 | OR, time to progression, toxicity | NCT00112463 |
