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. 2021 Dec 20;7:395. doi: 10.1038/s41420-021-00792-7

Fig. 5. Inhibition of Gln anaplerosis sensitizes cancer cells to chemotherapy.

Fig. 5

a Relative AREG mRNA levels in HCT116 and HeLa cells treated as indicated (n = 3). b Cell viability of HeLa cells treated with DOX in the presence of BPTES or DMKG (n = 3). Statistical differences were determined using a two-way ANOVA. Data represent the mean ± SD. c Cell death of HeLa cells treated with or without ETS in the presence of BPTES or DMKG (n = 3). d Cell viability of HCT116 or HeLa cells treated with the indicated chemotherapeutic agents in the presence of DMSO or BPTES (n = 3). All error bars ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001.