Table 1.
Identified protein myristoylation sites related to tumors
| Target | Function in cancer | Ref. |
|---|---|---|
| LAMTOR1 | Inhibits lysosomal degradation. | 588 |
| FMNL1/3 | Controls cytoskeleton remodeling and cellular morphological changes. | 202,465 |
| SFKs | Promotes membrane attachment and Src-family kinase activity. | 256 |
| TRAM | Enhances the membrane attachment for LPS and TRL7 signaling. | 432 |
| Fyn | Promotes subcellular location in immunological synapses and interaction with TCRζ chain. | 459,460 |
| c-Src | Regulates the activity of FAK in cell adhesion and extracellular matrix. | 72,461 |
| Lck | Promotes TCR signal cascade. | 448 |
| eNOS | Regulates enzyme activity and signal transduction. | 470 |
| Fus1 | Facilitates protein docking to the mitochondrial membrane. | 505 |
| BID | Improves its insertion into mitochondria membrane to enhance apoptosis. | 506 |
| PAK2 | Promotes protein location in membrane ruffles and internal membranes. | 507 |
| SAMM50, TOMM40, MIC19, and MIC25 | Promotes mitochondrial localization and membrane binding. | 589 |
| AMPK | Helps the removal of damaged mitochondria by autophagy. | 328 |
| AMPK | Enhances the β oxidation of fatty acids. | 590 |
| gelsolin | Regulate nuclear fragmentation or cytoskeletal remodeling during apoptosis. | 301 |
| DIC2 | ||
| Bap31 | ||
| MACF | ||
| YTHDF2 |