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. 2021 Dec 16;219(2):e20211381. doi: 10.1084/jem.20211381

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© 2021 Hoste et al.

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Figure S1. — Clinical data from patients with MIS-C and adults with severe COVID-19. (A) Timeline of symptoms, medical interventions, and time points of sampling for each of the 14 MIS-C patients included in the study. Treatment and dosages are denoted according to the legend. If tapering of corticosteroids was performed, partial circles are displayed according to the relative dose reductions that were applied. (B) Principal component (PC) analysis of routine laboratory data (top). Routine variables with missing data for individual patients (e.g., troponin, N-terminal pro-brain natriuretic peptide) were excluded from the analysis. Included variables are denoted in the vectors in the loadings plot (bottom). (C) Violin plots showing endotoxin levels in the plasma of MIS-C patients as compared with HCs. Dotted lines show median and quartiles. (D) Correlation plot of clinical variables of adult patients with severe COVID-19 and their routine laboratory parameters and biomarkers of endothelial and epithelial injury. Significance determined by Spearman’s rank correlation coefficients, indicated by *, P < 0.05; **, P < 0.01; and ***, P < 0.001. BMI, body mass index; PICU, pediatric intensive care unit; NIV, noninvasive ventilation; EU, endotoxin units; neutro, neutrophil; lympho, lymphocyte; eosino, eosinophil.