Fig. 4.
Essential dynamics analysis. (A) Plot of first 20 eigenvectors with associated eigenvalues (solid lines) and their cumulative percentage (dotted lines) of WT, V367F, R408I and G476S MTs, (B) Plot of first 20 eigenvectors with associated eigenvalues (solid lines) and their cumulative percentage (dotted lines) of WT, V483A and N501Y MTs, (C) Projection of PC1 vs PC2 of WT, V367F, R408I and G476S MTs and (D) Projection of PC1 vs PC2 of WT, V483A and N501Y MTs. WT, V367F, R408I, G476S, V483A and N501Y MTs were labelled in black, red, green, blue, magenta and yellow color, respectively.