Table 4.

Spearman correlation analysis between NTF3 and markers of immune cells in HCC.

Terms	Markers	R	p-value
T cell exhaustion	PDCD1 (PD-1)	0.103	*
	CTLA4	0.085	0.110
	LAG3	0.162	***
	HAVCR2 (TIM3)	0.211	***
	GZMB	0.138	**
	BTLA	0.203	***
	CD244 (SLAMF4)	0.382	***
	CD274 (PD-L1)	0.207	***
	CD96	0.296	***
	IDO1	−0.065	0.180
	KDR	0.319	***
	PDCD1LG2 (PD-L2)	0.323	***
	TGFBR1	−0.048	0.323
	TIGIT	0.174	***
T cell (general)	CD3E	0.273	***
	CD3G	0.24	***
	CD28	0.006	0.896
	CD2	0.18	***
CD8 + T cells	CD8A	0.276	***
	CD8B	0.205	***
CD4 + T cells	CD4	0.459	***
	CD40LG (CD40L)	0.283	***
	CXCR4	0.274	***
Th1	TBX21	0.252	***
	STAT4	0.212	***
	STAT1	−0.044	0.367
	IFNG	0.096	*
Th2	STAT6	−0.114	*
	STAT5A	−0.072	0.138
Tfh	BCL6	−0.113	*
	IL21	0.017	0.730
Th17	STAT3	−0.213	*
	IL17A	0.015	0.730
Treg	FOXP3	0.021	0.665
	STAT5B	−0.189	***
	TGFB1	0.223	***
	IL2RA (CD25)	0.075	0.124
B cell	CD19	0.213	***
	CD79A	0.393	***
Monocyte	CD86(B7-2)	0.226	***
	CSF1R	0.295	***
TAM	CCL2	0.51	***
	CD68	0.11	*
	IL10	0.324	***
M1 Macrophage	IRF5	−0.215	***
	PTGS2	0.642	***
M2 Macrophage	CD163	0.364	***
	VSIG4	0.389	***
	MS4A4A	0.261	***
Neutrophils	CEACAM8	0.066	0.178
	ITGAM	0.025	0.602
	CCR7	0.299	***
Natural killer cell	FCGR3A(CD16)	0.24	***
	NCAM1(CD56)	0.464	***
	KIR2DL1	0.153	**
	KIR2DL3	0.147	**
	KIR2DL4	0.043	0.379
	KIR3DL1	0.151	**
	KIR3DL2	0.161	***
	KIR2DS4	0.125	*
Dendritic cell	HLA-DRA	0.21	***
	HLA-DPA1	0.272	***
	CD1C	0.42	***
	NRP1	0.048	0.326
	ITGAX	0.047	0.339

TAM, Tumor-associated macrophages; Tfh, Follicular helper T cells; Treg, T regulatory cells.

^* P <0.05,

^** P < 0.01,

^***P < 0.001.