FIGURE 3.

NCCN analysis of polyQ amyloid structure. (A) 2D SQ-DQ spectrum from a NCCN measurement on polyQ amyloid fibrils, showing the main peaks of the two conformers called ‘a’ (red) and ‘b’ (blue) that make up the polyQ amyloid core. (B,C) Comparison of experimental S/S₀ values (horizontal lines) to simulated ψ-dependence S/S₀ ratios (black lines) for each conformer. (D) Ramachandran plot showing the integration of TALOS and NCCN analysis of the structures of polyQ amyloid conformers a and b. See also Figure 4 below. Figure adapted with permission from ref. (Hoop et al., 2016).