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. 2021 Dec 6;9:785410. doi: 10.3389/fcell.2021.785410

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Copyright © 2021 Xu, Anwaier, Ma, Liu, Tian, Su, Zhu, Shi, Wei, Xu, Qu, Ye and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunotherapy efficacy analysis of immunophenotyping clusters. (A–H) Expressions of immune checkpoint molecules, including PD-L1, PD-L2, LAG3, IL-8, PDCD1, CTLA-4, and TIGIT, and PBRM1, were compared using Students’ t test. (I) A total of 35 ccRCC patients receiving ICTs from the CA209-009 cohort with RNA-seq data and clinical responses to treatment. (J) Response status in 64 ccRCC patients receiving ICTs alone or combined with TKIs from the FUSCC cohort.