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. 2021 Dec 6;9:785410. doi: 10.3389/fcell.2021.785410

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Copyright © 2021 Xu, Anwaier, Ma, Liu, Tian, Su, Zhu, Shi, Wei, Xu, Qu, Ye and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prognostic implications and TME characterizations of immunophenotyping clusters in a real-world validation cohort. (A, B) A total of 360 ccRCC patients with long-term follow-up information from the FUSCC cohort were enrolled to identify the prognostic value of immunophenotyping clusters in the validation cohort. (C–G) Characteristics of the tumor microenvironment between immunophenotyping clusters were explored using (H, E) and immunohistochemical staining analysis in different clusters. (H) Opal multi-label IHC staining was used to identify the abundance of CD⁸⁺ T cells, CD⁴⁺FOXP³⁺ Treg cells, and CD³⁺CD⁴⁺CD⁸⁺ TCRn immune cell infiltration and PD-L1 expression in clusters.