Table 1.
Outcomes according to neonatal MRI*
| Normal/Mildly abnormal MRI (n=34) |
Moderately/Severely abnormal MRI (n=12) |
Total (n=46) |
P value | |
| Fidgety movements | 0.001† | |||
| Absent (−) | 3/31 (9.7) | 6/8 (75.0) | 9/39 (23.1) | |
| Sporadic (+/−) | 10/31 (32.3) | 0 | 10/39 (25.6) | |
| Intermittent (+) | 16/31 (51.6) | 2/8 (25.0) | 18/39 (46.2) | |
| Continual (++) | 1/31 (3.2) | 0 | 1/39 (2.6) | |
| Exaggerated | 1/31 (3.2) | 0 | 1/39 (2.6) | |
| Adverse outcome‡ | 5/32 (15.6) | 8/11 (72.7) | 13/43 (30.2) | <0.001 |
| Death | 0 | 4/12 (33.3) | 4/46 (8.7) | <0.001 |
| Bayley-III cognitive composite score | 0.001 | |||
| <70 | 0 | 3/7 (42.9) | 3/38 (7.9) | |
| 70–84 | 4/31 (12.9) | 1/7 (14.3) | 5/38 (13.2) | |
| ≥85 | 27/31 (87.1) | 3/7 (42.9) | 30/38 (78.9) | |
| Bayley-III motor composite score | 0.002 | |||
| <70 | 0 | 3/7 (42.9) | 3/38 (7.9) | |
| 70–84 | 3/31 (9.7) | 0 | 3/38 (7.9) | |
| ≥85 | 28/31 (90.3) | 4/7 (57.1) | 32/38 (84.2) | |
| Cerebral palsy | 1/31 (3.2) | 3/7 (42.9) | 4/38 (10.5) | 0.002 |
| GMFCS | ||||
| Level 1 | 1/31 (3.2) | 1/7 (14.3) | 2/38 (5.3) | |
| Level 5 | 0 | 2/7 (28.6) | 2/38 (5.3) |
Data are n/N (%). Denominators vary according to available data.
*Normal/Mildly abnormal MRI defined as normal/mild basal ganglia and thalami score and/or normal/mild/moderate white matter score. Moderately/Severely abnormal MRI defined as moderate/severe basal ganglia and thalami score and/or absent posterior limb of the internal capsule and/or severe white matter score.
†P value based on Fisher’s exact test on absent versus present FMs.
‡Adverse outcome defined as death, cerebral palsy with GMFCS level 3–5 or Bayley-III cognitive and/or motor composite score <85.
Bayley-III, Bayley Scales of Infant and Toddler Development (third edition); GMFCS, Gross Motor Function Classification System.