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. 2021 Sep 13;93(1):75–81. doi: 10.1136/jnnp-2021-327133

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Temporal differences in LDL and HDL cholesterol, ApoB and apoA1 and diagnosis of ALS. Participants going on to develop ALS (red) were each matched by age of sampling in years, date of sampling ±60 days and sex to 20 participants not going on to develop ALS (blue). Lines indicate linear model fit for ALS (red) and non-ALS (blue) participants. P values indicate interaction between ALS status and time, indicating difference in temporal trajectory of biomarkers over time. ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ALS, amyotrophic lateral sclerosis; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol.