Table 2.

Cox proportional hazards modelling for individual variables controlling for age at first study visit and sex

	All data					Excluding ALS within 5 years
	n	Cases	HR (95% CI)	P value	Adjusted p value	n	Cases	HR (95% CI)	P value	Adjusted p value
Total cholesterol	469 500	326	1.00 (0.90 to 1.12)	0.960	0.960	469 354	180	1.07 (0.93 to 1.24)	0.361	0.512
Total cholesterol:HDL ratio	429 710	294	1.17 (1.05 to 1.31)	0.006	0.031	429 578	162	1.19 (1.03 to 1.39)	0.022	0.123
LDL cholesterol	468 618	325	1.01 (0.91 to 1.12)	0.854	0.960	468 472	179	1.11 (0.96 to 1.28)	0.154	0.356
HDL cholesterol	429 789	294	0.84 (0.73 to 0.96)	0.010	0.035	429 657	162	0.81 (0.67 to 0.97)	0.022	0.123
Triglycerides	469 126	326	1.08 (0.97 to 1.20)	0.148	0.325	468 980	180	1.04 (0.90 to 1.20)	0.617	0.754
Apolipoprotein A1	427 427	291	0.83 (0.72 to 0.94)	0.005	0.031	427 297	161	0.83 (0.70 to 0.99)	0.043	0.157
Apolipoprotein B	467 121	324	1.01 (0.90 to 1.12)	0.916	0.960	466 976	179	1.11 (0.96 to 1.28)	0.162	0.356
HbA1c	466 412	323	0.98 (0.88 to 1.10)	0.770	0.960	466 267	178	0.93 (0.78 to 1.10)	0.373	0.512
Excess MET	402 300	275	0.93 (0.82 to 1.05)	0.259	0.475	402 179	154	0.99 (0.84 to 1.16)	0.882	0.882
BMI	499 314	336	1.04 (0.82 to 1.17)	0.444	0.698	499 166	188	1.08 (0.93 to 1.25)	0.302	0.512
Creatinine	469 268	326	0.86 (0.74 to 1.02)	0.076	0.210	469 122	180	0.96 (0.79 to 1.17)	0.696	0.765

Hazard ratios indicated for a 1 SD increase in variable level.

ALS, amyotrophic lateral sclerosis; BMI, body mass index; HbA1c, glycated haemoglobin A1c; HDL, high density lipoprotein; HR, hazard ratio; LDL, low density lipoprotein; MET, metabolic equivalent task.