Table 1.

Model parameters point estimate values and ranges

Parameters	Base-case	Range	Reference
Probabilities
Bloodstream infection at admission	0.05	0.04–0.06	10 21
Bloodstream infection in hospital	0.02	0.01–0.04	21
Progression to sepsis	0.20	0.12–0.26	21–24
Bloodstream infection-associated mortality, usual care	0.31	0.058–0.29	10
Sepsis-associated mortality, usual care	0.40	0.30–0.50	22 23
Bloodstream infection-associated mortality reduction, AMS	0.06	0.00–0.32	41
Health-related utilities
Well	0.74	0.48–0.83	31–34
Inpatient	0.64	0.54–0.73	28 29
Bloodstream infection	0.53	0.40–0.66	27 38
Sepsis	0.45	0.26–0.57	30
Costs (US$)
Cost of blood culture test, per patient	US$8	US$6–US$24	TASH, 2018
AMS staff time cost, per patient	US$3	US$1–US$6	TASH, 2018
Daily hospitalisation cost, per patient	US$5	US$1–US$35	TASH, 2018
Bloodstream treatment cost per hospital stay per patient, usual care	US$1872	US$255–US$2821	TASH, 2018
Bloodstream treatment cost per hospital stay, AMS	US$289	US$255–US$2821	TASH, 2018
Total cost of automated blood culture platform including consumables and technologist training cost	US$97 464	US$80 000–US$150 000	SLP, 2018

AMS, antimicrobial stewardship; SLP, Setema Limited Plc; TASH, Tikur Anbessa Specialised Hospital.