Table 1.
Model parameters point estimate values and ranges
Parameters | Base-case | Range | Reference |
Probabilities | |||
Bloodstream infection at admission | 0.05 | 0.04–0.06 | 10 21 |
Bloodstream infection in hospital | 0.02 | 0.01–0.04 | 21 |
Progression to sepsis | 0.20 | 0.12–0.26 | 21–24 |
Bloodstream infection-associated mortality, usual care | 0.31 | 0.058–0.29 | 10 |
Sepsis-associated mortality, usual care | 0.40 | 0.30–0.50 | 22 23 |
Bloodstream infection-associated mortality reduction, AMS | 0.06 | 0.00–0.32 | 41 |
Health-related utilities | |||
Well | 0.74 | 0.48–0.83 | 31–34 |
Inpatient | 0.64 | 0.54–0.73 | 28 29 |
Bloodstream infection | 0.53 | 0.40–0.66 | 27 38 |
Sepsis | 0.45 | 0.26–0.57 | 30 |
Costs (US$) | |||
Cost of blood culture test, per patient | US$8 | US$6–US$24 | TASH, 2018 |
AMS staff time cost, per patient | US$3 | US$1–US$6 | TASH, 2018 |
Daily hospitalisation cost, per patient | US$5 | US$1–US$35 | TASH, 2018 |
Bloodstream treatment cost per hospital stay per patient, usual care | US$1872 | US$255–US$2821 | TASH, 2018 |
Bloodstream treatment cost per hospital stay, AMS | US$289 | US$255–US$2821 | TASH, 2018 |
Total cost of automated blood culture platform including consumables and technologist training cost | US$97 464 | US$80 000–US$150 000 | SLP, 2018 |
AMS, antimicrobial stewardship; SLP, Setema Limited Plc; TASH, Tikur Anbessa Specialised Hospital.