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. 2021 Dec 17;11(12):e047515. doi: 10.1136/bmjopen-2020-047515

Table 1.

Model parameters point estimate values and ranges

Parameters Base-case Range Reference
Probabilities
 Bloodstream infection at admission 0.05 0.04–0.06 10 21
 Bloodstream infection in hospital 0.02 0.01–0.04 21
 Progression to sepsis 0.20 0.12–0.26 21–24
 Bloodstream infection-associated mortality, usual care 0.31 0.058–0.29 10
 Sepsis-associated mortality, usual care 0.40 0.30–0.50 22 23
 Bloodstream infection-associated mortality reduction, AMS 0.06 0.00–0.32 41
Health-related utilities
 Well 0.74 0.48–0.83 31–34
 Inpatient 0.64 0.54–0.73 28 29
 Bloodstream infection 0.53 0.40–0.66 27 38
 Sepsis 0.45 0.26–0.57 30
Costs (US$)
 Cost of blood culture test, per patient US$8 US$6–US$24 TASH, 2018
 AMS staff time cost, per patient US$3 US$1–US$6 TASH, 2018
 Daily hospitalisation cost, per patient US$5 US$1–US$35 TASH, 2018
 Bloodstream treatment cost per hospital stay per patient, usual care US$1872 US$255–US$2821 TASH, 2018
 Bloodstream treatment cost per hospital stay, AMS US$289 US$255–US$2821 TASH, 2018
 Total cost of automated blood culture platform including consumables and technologist training cost US$97 464 US$80 000–US$150 000 SLP, 2018

AMS, antimicrobial stewardship; SLP, Setema Limited Plc; TASH, Tikur Anbessa Specialised Hospital.