Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 6;12:745646. doi: 10.3389/fphar.2021.745646

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Li, Wang, Liu, Zhai, Zhang, Ying, Jia, Xue, Meng, Li, Wu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

N6 inhibits HTNV without direct virucidal activity (A) The cytotoxicity assay showed that the survive rate of A549 cells treated by N6 ranging from 1 to 100 μM was more than 80%, and CC50 of N6 was 77.08 ± 0.56 μM (B) N7 inhibited the proliferation of A549 cells with CC50 at 64.78 ± 0.53 μM (C) N6 and N7 displayed an anti-HTNV activity in a dose-dependent manner with EC50 at 7.06 ± 1.05 μM and 11 ± 0.76 μM, respectively (D) Western blot assay showed that pretreatment of 10 μM N6 could not affect HTNV infectivity at 96 hpi at room temperature (lane b) or 37°C (lane c). Results of the statistical analyses are depicted as follows: Student’s t test or one-way ANOVA; ns, p > 0.05, n = 3.