Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 6;12:745646. doi: 10.3389/fphar.2021.745646

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Li, Wang, Liu, Zhai, Zhang, Ying, Jia, Xue, Meng, Li, Wu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Binding site and model of N6 with AKT1 (A) Overview of the docked pose between the N6 and binding pocket to the active site of Akt1 (B) The close view of the interaction between N6 and the active site of Akt1 (C) In the analyzed result of the aromatic ring edges or faces, the negative values (blue) correspond to the edges of aromatic rings, whereas the positive values (orange) correspond to the faces of aromatic rings (D) In the analyzed result of the hydrophobicity, the negative values (blue) correspond to hydrophilic residues, whereas the positive values (brown) correspond to hydrophobic residues (E) In the analyzed result of the hydrogen bond, the negative values (green) correspond to hydrogen bond acceptors, whereas the positive values (magenta) correspond to hydrogen bond donors (F) In the analyzed result of the ionizability, the negative values (red) correspond to acidic residues, whereas the positive values (blue) correspond to basic residues (G) In the analyzed result of the atomic charge, values less than −0.1 are mapped in red, and values larger than +0.1 are mapped in blue (H) In the analyzed result of the solvent accessibility surface, small values (green) correspond to buried residues, whereas large values (blue) correspond to exposed residues.