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. 2021 Dec 6;12:788558. doi: 10.3389/fphar.2021.788558

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Copyright © 2021 Li, Wang, Chen, Zhou, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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α-diversity and β-diversity analyses of the gut microbiota in mice at the different stages of NAFLD. (A) Sobs index, Shannon index, ACE index, and Chao1 index on the OTU level. (B) PCA analysis. (C) PCoA analysis based on Bray-Curtis distance. Values represent mean ± standard deviation with *p < 0.05, ***p < 0.001 and ns vs HFHC_12w group. Abbreviation: NAFLD, non-alcoholic fatty liver disease; OTU, Operational taxonomic unit; PCA, principal component analysis; PCoA, principal coordinate analysis; HFHC, high-fat high-cholesterol; ns, not significant.