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. 2021 Dec 6;12:788558. doi: 10.3389/fphar.2021.788558

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Copyright © 2021 Li, Wang, Chen, Zhou, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered gut microbiome at the different stages of NAFLD. Relative abundance of bacterial communities from mice at the different stages of NAFLD at the phylum (A) and genus level (B). Comparison of average abundance of specific gut bacteria from mice at the different stages of NAFLD at the phylum (C) and genus level (D). Values represent mean ± standard deviation with *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.000 vs HFHC_12w group. Abbreviation: NAFLD, non-alcoholic fatty liver disease; HFHC, high-fat high-cholesterol.