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. 2021 Dec 6;12:788558. doi: 10.3389/fphar.2021.788558

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Copyright © 2021 Li, Wang, Chen, Zhou, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UDCA partially restored the gut microbiome in NASH mice. Relative abundance of bacterial communities from mice in ND-control, HFHC-control and HFHC-UDCA (120 mg/kg) group at the phylum (A) and genus level (C). Comparison of average abundance of certain gut bacteria from mice in ND-control, HFHC-control and HFHC-UDCA (120 mg/kg) group at the phylum (B) and genus level (D). Values represent mean ± standard deviation with *p < 0.05, **p < 0.01, ***p < 0.001 and ns vs HFHC-control group. Abbreviation: UDCA, ursodeoxycholic acid; NASH, non-alcoholic steatohepatitis; ND, normal diet; HFHC, high-fat high-cholesterol; ns, not significant.