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. 2021 Dec 6;12:788558. doi: 10.3389/fphar.2021.788558

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Copyright © 2021 Li, Wang, Chen, Zhou, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UDCA protects against intestinal barrier disruption and reduces serum LPS and inflammatory cytokines in NASH mice. (A) H&E staining of mouse intestinal tissue from ND-control, HFHC-control and HFHD-UDCA (120 mg/kg) group. (B) Comparison of the Chiu score for mouse intestinal tissue from ND-control, HFHC-control, and HFHD-UDCA (120 mg/kg) groups. (C) Immunohistochemistry staining for ZO-1 and Claudin-1 expression in the mouse intestine from ND-control, HFHC-control, and HFHD-UDCA (120 mg/kg) groups. (D) Comparison of H-score for the immunohistochemical evaluation of ZO-1 and Claudin-1 expression in the mouse intestine from ND-control, HFHC-control, and HFHD-UDCA (120 mg/kg) groups. (E) UDCA treatment reduces serum LPS and inflammatory cytokines in NASH mice. Values represent mean ± standard deviation with *p < 0.05, **p < 0.01, ***p < 0.001 and ns vs HFHC-control group. Abbreviation: UDCA, ursodeoxycholic acid; LPS, lipopolysaccharide; NASH, non-alcoholic steatohepatitis; HFHC, high-fat high-cholesterol; ND, normal diet; ns, not significant.