Table 2.
Univariate and multivariate analyses with respect to the probability of detecting CSF ctDNA
| Factor | Univariate analysis |
Multivariate analysisa |
||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age (≥56 versus <56 years) | 0.76 (0.28-2.03) | 0.59 | NA | NA |
| Sex (male versus female) | 1.23 (0.44-3.38) | 0.69 | NA | NA |
| Histology (LUAD versus others) | 1.11 (0.32-3.65) | 0.87 | NA | NA |
| Smoking (ever versus never) | 1.08 (0.39-3.08) | 0.88 | NA | NA |
| CNS symptom (yes versus no) | 1.69 (0.62-4.71) | 0.31 | NA | NA |
| Tsize | 1.08 (1.02-1.17) | 0.02b | 1.11 (1.03-1.22) | 0.01b |
| LLVD | 0.90 (0.84-0.96) | 0.002b | 0.94 (0.87-1.01) | 0.12 |
| LVDmin | 0.88 (0.81-0.95) | 0.002b | 0.87 (0.78-0.96) | 0.009b |
CI, confidence interval; CNS, central nervous system; CSF, cerebrospinal fluid; ctDNA, circulating tumor DNA; LLVD, shortest lesion–ventricle distance for the largest lesion; LUAD, lung adenocarcinoma; LVDmin, minimum lesion–ventricle distance for all intracranial lesions; NA, not available; OR, odds ratio; Tsize, the maximum diameter of the largest intracranial lesion.
a
NA: These variables were eliminated in the multivariate logistic regression model, and thus, the OR and P values are not available.
b
P < 0.05.