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. 2021 Dec 15;3(1):101023. doi: 10.1016/j.xpro.2021.101023

Figure 1.

Figure 1

Localization of mutations detected by the script

(A) All mutations found in the pan-cancer cohort in TCGA (Urbanek-Trzeciak et al., 2020).

(B) Mutations found within miR-205 in the pan-cancer cohort in TCGA (Urbanek-Trzeciak et al., 2020). miRNA duplex positions are indicated in blue, and seed regions are indicated in dark blue. The flanking regions and terminal positions of the apical loop are indicated in gray. The numbers in the lower right corner represent the number of plotted mutations (upper) and the number of mutated miRNA genes (lower; not provided for mutations shown within a single miRNA gene). If present, sequence variants localized beyond position 22 in longer mature miRNAs are cumulatively shown at position 22. The plot shows mutations within six positions of the loop (first 3 and last 3 nucleotides). The number of the remaining loop mutations is indicated within the loop.