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. 2021 Dec 1;12:752782. doi: 10.3389/fimmu.2021.752782

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Copyright © 2021 Wong, Buckner, Lage, Pei, Assis, Dahlstrom, Anzick, Virtaneva, Rupert, Davis, Zhou, Laidlaw, Manion, Galindo, Anderson, Seamon, Sneller, Lisco, Deleage, Pittaluga, Moir and Sereti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LN histologic characterization. (A) Representative images of H&E staining of LN from HC, HIV⁺ pre- and post-ART participants (identifiers in S1 Table ) depicting the four groups: quiescent (L017 pre-ART), follicular involution with paracortical hyperplasia (L090 pre-ART and HC6), lymphocyte depletion (L061 pre-ART), and follicular hyperplasia (L003 post-ART); 20X and 100X magnification. (B) Pie charts depicting proportion of LN pre-ART (n = 21) and post-ART (n = 21) characterized as quiescent (Q), follicular involution with paracortical hyperplasia (FIPH), lymphocyte depletion (LD), follicular hyperplasia (FH), and other (OTH). s(C) Proportion of LN pre-ART (n = 17) and post-ART (n = 19) that were grouped as FH or non-FH. **p < 0.01 by Fisher’s exact test.