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. 2021 Dec 1;12:752782. doi: 10.3389/fimmu.2021.752782

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Copyright © 2021 Wong, Buckner, Lage, Pei, Assis, Dahlstrom, Anzick, Virtaneva, Rupert, Davis, Zhou, Laidlaw, Manion, Galindo, Anderson, Seamon, Sneller, Lisco, Deleage, Pittaluga, Moir and Sereti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional profiling on samples from PB and LN. (A) RNAseq of HIV⁺ participant longitudinal samples from PB (n = 12) and LN (n = 11). Differentially expressed genes pre/post ART filtered by a fold change of 1.3, then analyzed by Ingenuity pathway analysis (IPA). Listed are the most significantly enriched pathways. (B) Depiction of Type I/II interferon signaling pathway, the most enriched pathway in both PB and LN; green indicates genes significantly downregulated post-ART. (C) Principal component analysis (PCA) distinguishing PB (open) and LN (closed) compartments and pre- (green) and post- (red) ART time-points (left panel); PB (middle) and LN (right) panels distinguishing pre- (green) and post- (red) ART time-points and gender: female (triangle) and male (circle). (D) Pie chart of LN samples showing percentage of HIV⁺ participant samples with GC-related and non-GC-related genes that underwent a 1.3-fold or more change post-versus pre- ART. (E) Correlation matrix of fold changes of plasma biomarkers versus normalized transcripts of interferon related genes (n = 10).