TABLE 3.
Odds ratios (OR) with 95% confidence intervals (CI) for venous thromboembolism (VTE), deep vein thrombosis, and pulmonary embolism, per standard deviation (SD) increase and across increasing quartiles of procoagulant phospholipid (PPL) clotting time (s)
| PPL clotting time (s) |
Cases n |
Controls n |
Model 1 OR (95% CI) |
Model 2 OR (95% CI) |
Model 3 OR (95% CI) |
|---|---|---|---|---|---|
| Venous thromboembolism | |||||
| Per SD | 296 | 674 | 0.94 (0.81–1.08) | 0.93 (0.80–1.07) | 0.95 (0.82–1.10) |
| Q1 (26.5–54.3) | 83 | 169 | 1 (ref) | 1 (ref) | 1 (ref) |
| Q2 (54.3–63.5) | 74 | 169 | 0.89 (0.61–1.30) | 0.87 (0.59–1.27) | 0.84 (0.57–1.24) |
| Q3 (63.5–74.5) | 63 | 167 | 0.77 (0.52–1.13) | 0.75 (0.51–1.12) | 0.77 (0.51–1.15) |
| Q4 (74.5–148.5) | 76 | 169 | 0.92 (0.63–1.34) | 0.89 (0.60–1.30) | 0.94 (0.64–1.40) |
| ≤25% (26.5–54.3) | 83 | 169 | 1 (ref) | 1 (ref) | 1 (ref) |
| >95% (89.9–148.5) | 6 | 34 | 0.36 (0.13–0.83) | 0.35 (0.13–0.81) | 0.32 (0.10–0.78) |
| Deep vein thrombosis | |||||
| Per 1 SD increase | 174 | 674 | 0.98 (0.83–1.17) | 0.97 (0.82–1.15) | 0.98 (0.82–1.18) |
| Q1 (26.5–54.3) | 50 | 169 | 1 (ref) | 1 (ref) | 1 (ref) |
| Q2 (54.3–63.5) | 32 | 169 | 0.64 (0.39–1.05) | 0.63 (0.38–1.03) | 0.57 (0.34–0.94) |
| Q3 (63.5–74.5) | 47 | 167 | 0.96 (0.61–1.51) | 0.95 (0.60–1.49) | 0.90 (0.59–1.51) |
| Q4 (74.5–148.5) | 45 | 169 | 0.91 (0.57–1.43) | 0.87 (0.55–1.38) | 0.90 (0.56–1.45) |
| ≤25% (26.5–54.3) | 50 | 169 | 1 (ref) | 1 (ref) | 1 (ref) |
| >95% (89.9–148.5) | 5 | 34 | 0.50 (0.16–1.25) | 0.50 (0.16–1.25) | 0.43 (0.12–1.15) |
| Pulmonary embolism | |||||
| Per 1 SD increase | 122 | 674 | 0.88 (0.71–1.06) | 0.87 (0.71–1.06) | 0.90 (0.73–1.11) |
| Q1 (26.5–54.3) | 33 | 169 | 1 (ref) | 1 (ref) | 1 (ref) |
| Q2 (54.3–63.5) | 42 | 169 | 1.26 (0.76–2.09) | 1.22 (0.73–2.04) | 1.23 (0.74–2.08) |
| Q3 (63.5–74.5) | 16 | 167 | 0.49 (0.25–0.90) | 0.48 (0.25–0.89) | 0.51 (0.26–0.95) |
| Q4 (74.5–148.5) | 31 | 169 | 0.92 (0.54–1.58) | 0.89 (0.52–1.54) | 0.98 (0.56–1.71) |
| ≤25% (26.5–54.3) | 33 | 169 | 1 (ref) | 1 (ref) | 1 (ref) |
| >95% (89.9–148.5) | 1 | 34 | 0.15 (0.01–0.72) | 0.14 (0.01–0.69) | 0.15 (0.01–0.76) |
Model 1: adjusted for age and sex. Model 2: adjusted for age, sex, and body mass index. Model 3: age, sex, body mass index, history of cardiovascular disease, cancer, and platelet count. 1 standard deviation (SD) of PPLCT = 14.5 s.