Fig. 3.

a Schematic illustration of Panc02 tumor implantation, treatment, and monitoring. b NIR thermal photos of Panc02 tumor-bearing mice under laser irradiation at 24 h post-injection of 200 μL of PBS (control), or 300 µg/mL CNS₀, CNS_C, CNS_J, or CNS_D via tail-vein injection. c Temperature increase curves in the tumor areas of Panc02 tumor-bearing mice after administration of PBS (control), CNS₀, CNS_C, CNS_J, and CNS_D under NIR-II laser illumination (1064 nm, 1 W cm⁻², 5 min). d, e Relative tumor volumes of primary mass (d) and distant masses (e) in Panc02 tumor-bearing C57BL/6 mice (n = 5) intravenously administered with 200 μL of PBS or 300 µg/mL CNS₀, CNS_C, CNS_J, or CNS_D in the presence and absence of photoirradiation. f The tumor weight of primary masses and distant masses in the Panc02 tumor-bearing C57BL/6 mice (n = 5) in the control, CNS₀, CNS_C, CNS_J, and CNS_D groups at the end of treatments. g The representative H&E, TUNEL, and Ki-67 immunofluorescence staining images of primary tumors in various groups (the scale bar represents 50 μm). *p < 0.05, ***p < 0.001