Table 7.
Functional characterization of XIST in other system tumors
| Tumor types | Expression | Role | Function role | miRNAs | Related genes | References |
|---|---|---|---|---|---|---|
| Osteosarcoma | Upregulation | Oncogene | Proliferation and invasion | miR-137 | / | Li et al. 2019b) |
| Osteosarcoma | Upregulation | Oncogene | Proliferation and invasion | miR-320b | RAP2B | Lv et al. 2018) |
| Osteosarcoma | Upregulation | Oncogene | Proliferation and invasion | miR-193a-3p | RSF1 | Wu et al. 2017b) |
| Osteosarcoma | Upregulation | Oncogene | Proliferation, autophagy, and apoptosis | miR-375-3p | AKT/mTOR | Sun et al. 2019) |
| Osteosarcoma | Upregulation | Oncogene | Migration, invasion, and emt | miR-153 | SNAIL | Wen et al. 2020) |
| Osteosarcoma | Upregulation | Oncogene | Proliferation and apoptosis | miR-124-3p | iASPP | Hai et al. 2021) |
| Bladder cancer | Upregulation | Oncogene | Clone formation and emt | miR-200c | / | Xu et al. 2018a) |
| Bladder cancer | Upregulation | Oncogene | Proliferation and migration | miR-133a | / | Zhou et al. 2019) |
| Bladder cancer | Upregulation | Oncogene | Proliferation, migration, and invasion | miR-124 | AR | Xiong et al. 2017) |
| Bladder cancer | Upregulation | Oncogene | Proliferation, migration, invasion, and apoptosis | miR-139-5p | Wnt/β-catenin | Hu et al. 2017) |
| Bladder cancer | Upregulation | Oncogene | Proliferation, migration, invasion, and emt | miR-335 | / | Chen et al. 2020) |
| Retinoblastoma | Upregulation | Oncogene | Proliferation, invasion, apoptosis, and emt | miR-142-5p | / | Xu and Tian 2020) |
| Retinoblastoma | Upregulation | Oncogene | Proliferation, cell cycle, and apoptosis | miR-124 | STAT3 | Hu et al. 2018) |
| Retinoblastoma | Upregulation | Oncogene | Proliferation, migration, invasion, apoptosis, and emt | miR-101 | ZEB1/ZEB2 | Cheng et al. 2019) |
| Retinoblastoma | Upregulation | Oncogene | Proliferation and invasion | miR-140-5p | SOX4 | Wang et al. 2020d) |
| Retinoblastoma | Upregulation | Oncogene | Proliferation, invasion, apoptosis, and emt | miR-200a-3p | NRP1 | Zhao et al. 2020) |
| Retinoblastoma | Upregulation | Oncogene | Proliferation, migration, invasion, autophagy, and apoptosis | miR-361-3p | STX17 | Yang et al. 2020) |
| Retinoblastoma | Upregulation | Oncogene | Proliferation, autophagy, and drug sensitivity | miR-204-5p | / | Yao et al. 2020) |
| Cervical cancer | Upregulation | Oncogene | Proliferation, apoptosis, invasion, and emt | miR-200a | Fus | Zhu et al. 2018a) |
| Cervical cancer | Upregulation | Oncogene | Proliferation and apoptosis | miR-140-5p | ORC1 | Chen et al. 2019b) |
| Cervical cancer | Upregulation | Oncogene | Proliferation, migration, invasion, and apoptosis | miR-889-3p | SIX1 | Liu et al. 2020) |
| Thyroid cancer | Upregulation | Oncogene | Proliferation, migration, and invasion | miR-141 | / | Xu et al. 2018b) |
| Thyroid cancer | Upregulation | Oncogene | Proliferation | miR-34a | MET-PI3K-AKT | Liu et al. 2018) |
| Thyroid cancer | Upregulation | Oncogene | Migration and invasion | miR-101-3p | CLDN1 | Du et al. 2021) |
| Nasopharyngeal cancer | Upregulation | Oncogene | Growth | miR-34a-5p | E2F3 | Song et al. 2016) |
| Nasopharyngeal cancer | Upregulation | Oncogene | Proliferation and radiosensitivity | miR-29c | / | Han et al. 2017) |
| Nasopharyngeal cancer | Upregulation | Oncogene | Proliferation, invasion, and apoptosis | miR-491-5p | / | Cheng et al. 2018) |
| Nasopharyngeal cancer | Upregulation | Oncogene | Proliferation, metastasis, and emt | miR-148a-3p | ADAM17 | Shi et al. 2020) |
| Nasopharyngeal cancer | Upregulation | Oncogene | Glycolysis, migration, and invasion | miR-381-3p | NEK5 | Zhao et al. 2020) |
| Melanoma | Upregulation | Oncogene | Proliferation and apoptosis | miR-23a-3p | GINS2 | Hao et al. 2021) |
| Leukemia | Upregulation | Oncogene | Drug resistance, viability, and apoptosis | miR-29a | MYC | Wang et al. 2020a) |