Table 1a.
Characteristics of studies on ASD included in analysis.
| Study, Year | No. of Cases of ASD | Exposure Assessment | Exposure Timing and Type |
|---|---|---|---|
| Croen et al, [9] 2011 | Exposed: 15/49Not exposed: 283/1756 | Prescription dispensing | All trimesters: SSRI's, SNRI's |
| Hviid et al, [14] 2013 | Exposed: 52/6068Not exposed: 3752/620807 | DBL | All trimesters: citalopram, fluoxetine, sertraline, escitalopram, fluvoxamine. |
| Rai et al, [11] 2013 | Exposed: 14/85Not exposed: 1665/18439 | DBL and maternal reports. | SSRI's and Non-SSRI's (monoamine reuptake inhibitors) |
| Sorensen et al, [15] 2013 | Exposed: 104/8833Not exposed: 5333/646782 | Prescription dispensing | All trimesters: SSRI's, SNRI's and TCAs. |
| Gidaya et al, [10] 2014 | Exposed: 76/441Not exposed: 5139/56924 | DBL | All trimesters: fluoxetine, citalopram sertraline, fluvoxamine, paroxetine, escitalopram. |
| Harrington et al, [16] 2014 | Exposed: 29/40Not exposed: 463/772 | Telephone interviews and DBL (when available). | All trimesters: fluoxetine, sertraline, paroxetine, citalopram, escitalopram. |
| Clements et al, [1] 2015 | Exposed: 40/121Not exposed: 1337/5278 | Prescription dispensing | All trimesters: Serotonergic and non-SSRI's antidepressants. |
| Boukhris et al, [12] 2016 | Exposed: 46/4724Not exposed: 1008/140732 | DBL and maternal reports. | All trimesters: SSRI's, SNRI's, TCAs, MAOIs and other. |
| Malm et al, [13] 2016 | Exposed: 88/15729Not exposed: 100/31394 | Prescription dispensing | All trimesters: fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine, escitalopram. |
| Brown et al, [17] 2017 | Exposed: 58/2837Not exposed: 335/33069 | DBL and prescription dispensing. | First to third trimester: SSRI's or SNRI's. |
| Rai et al, [18] 2017 | Exposed: 136/3342Not exposed: 353/12352 | DBL and maternal reports. | All trimesters: SSRI's and others. |
| Sujan et al, [19] 2017 | Exposed: 299/22544Not exposed: 14318/1558085 | DBL and maternal reports. | First trimester: Any antidepressant |
| Viktorin et al, [20] 2017 | Exposed: 85/3982Not exposed: 1524/172646 | DBL | All trimesters: SSRI's, SNRI's and others. |
| Wilcox-Hagberg et al, [21] 2017 | Exposed: 324/20355Unexposed: 1696/168797 | DBL | All trimesters: SSRI's, SNRI's, TCA's and others. |
| Yamamoto-Sasaki et al, [22] 2019 | Exposed: 7/195Not exposed: 423/26730 | DBL | All trimesters: SSRI's, SNRI's and others. |