Study	Species	Sexes	Sexes Combined or Separated	Sample Size	Singular/ Chronic Dosing	Chronic Timing	Dose (mg/kg)	Route	Treatment Age (PD)	Testing Age (PD)	Temperature (°C)	Social Restriction	Males	Females	Both
Kirilly 2010 [224]	Rat	Males	NA	NA	Chronic	Twice	15	i.p.	42-49	21 days later, and once on testing day	21	14 days	Acute: decreased aggressive-type behaviour. 1st dose: decreased biting, boxing.	NA	NA
Kurling 2008 [225]	Rat	Males	NA	12	Singular	NA	1, 5	i.p.	“Adult” (300–380g)	Same day	21	6 days	Increased locomotor activity, rearing bouts, agitation, stereotyped sniffing, head/body weaving, head bobbing.	NA	NA
Machalova 2012 [79]	Mouse	Males	NA	98	Singular	NA	2.5, 10, 30	i.p.	“Juvenile” (18-20g)	Same day	22	Not specified	Aggressive mice: decreased aggression, increased timidity (defensive posture; 30 mg/kg: escape; 10, 30 mg/kg: alert posture); 2.5, 10 mg/kg: increased social behaviour (2.5 mg/kg: social sniffing; 2.5, 10 mg/kg: conspecific-following); 30 mg/kg: walking. Timid mice: 10, 30 mg/kg: increased timidity (increased alter- posture frequency); 30 mg/kg: increased escape frequency. Decreased social behaviour frequency (social sniffing; 10, 30 mg/kg: conspecific-following). 30 mg/kg: walking.	NA	NA
Maldonado 2001 [226]	Mouse	Males	NA	NA	Singular	NA	0.5, 1.25, 2.5	i.p.	NA	Same day	NA	NA	0.5, 1.25 mg/kg: decreased shorter inter-attack intervals	NA	NA
Maldonado 2001 [88]	Mouse	Males	NA	60	Singular	NA	1, 8, 15	i.p.	“Juvenile” (25-30g)	Same day	21	30 days (for aggression)	8, 15 mg/kg: decreased grooming, digging, social exploration, threat/attack time. 8, 15 mg/kg: increased non-social exploration, defence/submission, distance exploration, avoidance. 1 mg/kg: increased distant exploration, avoidance.	NA	NA
McGregor 2003 [92]	Rat	Males	NA	24	Chronic	Each of 4 hours over 2 consecutive days	5	i.p.	90	160	28	Nil	Decreased social interaction time and frequency.	NA	NA
McGregor 2003 [92]	Rat	Males	NA	24	Singular	NA	5	i.p.	90	160	28	Nil	Decreased social interaction time.	NA	NA
McGregor 2003 [77]	Rat	Males	NA	32	Chronic	Each of 4 hours over 2 consecutive days	5	i.p.	60-75	56-70 days later	28, 16	Nil	Less social interaction, fewer social-interaction bouts.	NA	NA
Miczek 1994 [227]	Mouse	Males	NA	29	Singular	NA	0.3, 3, 6, 10	NA	“Adult”	“Adult”	21	Nil	3-10 mg/kg: decreased frequency of attacks > decreased dose-dependent sideways threats.	NA	NA