Study	Species	Sexes	Sexes Combined or Separated	Sample Size	Singular/ Chronic Dosing	Chronic Timing	Dose (mg/kg)	Route	Treatment Age (PD)	Testing Age (PD)	Temperature (°C)	Social Restriction	Males	Females	Both
Piper 2008 [205]	Rat	Males	NA	20-24	Chronic	4 doses, 1 each hour	10	s.c.	“Young adult” (307.7g)	“Young adult”	23	Nil	No effect.	NA	NA
Procopio-Souza 2011 [85]	Mouse	Males	NA	24	Chronic	Acute dose, then repeat 10 days later	10	i.p.	90	90, 100	22-23	NA	Increased locomotor frequency (housing: group > individual). Group-housed: increased social-interaction time. 2nd dose: higher locomotion frequency; group-housed: repeated dosing did not modify social behavior; but increased body contact, peaceful following; decreased anogenital sniffing.	NA	NA
Ramos 2013 [229]	Rat	Males	NA	32	Singular	NA	2.5, 5	i.p.	“Adult” (250-300g)	Same day	23	1 hour	5 mg/kg: increased adjacent-lying time, decreased anogenital sniffing and rearing.	NA	NA
Ramos 2015 [230]	Rat	Males	NA	10	Singular	NA	5	i.p.	“Adult” (250-300g)	“Adult” (250-300g)	21	Nil	More time spent in physical contact with a conspecific (but this also occurred with an inanimate object).	NA	NA
Rodriguez-Arias 2011 [231]	Mouse	Males	NA	40	Chronic	Twice, 4 hours apart, on each of 2 days, 6 days apart	10, 20	i.p.	41, 42	64	21	Nil	20 mg/kg: less social-investigation time, less threat and attack times, more non-social exploration time.	NA	NA
Rodriguez-Arias 2015 [232]	Mouse	Males	NA	179	Chronic	Twice daily (4-hour intervals), over 2 consecutive days a week	10, 20	i.p.	33, 34, 40, 41	75	21	Nil	More aggression (10, 20 mg/kg: more attacks; 10 mg/kg: more threats). 10 mg/kg: more time in social investigation, less time in non-social investigation.	NA	NA
Shen 2011 [233]	Rat	Males	NA	60	Chronic	Twice every 5th day	10	s.c.	52-62	72	26	7 days	Reduced crawling frequency and time.	NA	NA
Slais 2005 [234]	Mouse	Both	NA	NA	Chronic	2.5 mg/kg: once daily for 5 consecutive days; 30 mg/kg: 8 days later	2.5, 30	p.o.	NA	NA	NA	Nil	Decreased aggression in aggressive mice, decreased prosocial behaviour in timid mice. Increased defence-escape behaviour. MDMA pre-treatment (2.5 mg/kg) had no effect.	-	-
Slais 2005 [235]	Mouse	Males	NA	NA	Singular	NA	2.5, 10, 30	p.o.	NA	NA	NA	Always	Decreased aggression, increased sociability and defence-escape behaviours in aggressive mice. Increased defence-escape behaviour and decreased sociability in timid mice.	NA	NA