Study	Species	Sexes	Sexes Combined or Separated	Sample Size	Singular/ Chronic Dosing	Chronic Timing	Dose (mg/kg)	Route	Treatment Age (PD)	Testing Age (PD)	Temperature (°C)	Social Restriction	Males	Females	Both
Slais 2009 [236]	Mouse	NA	NA	49	Chronic	Twice, 1-week interval	2.5, 10, 30	p.o.	NA	NA	NA	Nil	Aggressive mice: decreased aggression and sociability, increased defence-escape behaviour; 30 mg/kg: increased walking. Timid mice: increased defence-escape behaviour, decreased prosociality; 30 mg/kg: increased walking	-	-
Slamberova 2015 [97]	Rat	Males	NA	246	Singular	NA	2.5, 5.0, 10	s.c.	“Adult”	Same day	22-24	Nil	Decreased time and frequency of mutual sniffing. 10 mg/kg: decreased frequency of mutual sniffing and following. Decreased time and frequency of climbing over conspecific. 5, 10 mg/kg: decreased rearing frequency, time and frequency of allogrooming.	NA	NA
Thompson 2004 [237]	Rat	Males	NA	25	Chronic	Each of 4 hours on 2 consecutive days	5	i.p.	332g	84-105 days later	28	Nil	Less time in social interaction.	NA	NA
Thompson 2007 [52]	Rat	Males	NA	16	Singular	NA	5	i.p.	403g	403g	28	Nil	Increased adjacent lying; decreased general investigation, anogenital investigation and rearing.	NA	NA
Thompson 2008 [83]	Rat	Males	NA	48	Chronic	Each of 4 hours over 2 consecutive days	5	i.p.	6-16	90-100	28	20 mins.	Chronically decreased total social interaction.	NA	NA
Thompson 2008 [83]	Rat	Males	NA	48	Chronic	Each of 4 hours over 2 consecutive days	2.5	i.p.	9-19	90-100	28	20 mins.	Decreased investigation.	NA	NA
Thompson 2008 [83]	Rat	Males	NA	48	Singular	NA	5	i.p.	8-18	90-100	28	20 mins.	2.5 mg/kg: decreased total social interaction, adjacent lying.	NA	NA
Thompson 2009 [82]	Rat	Males	NA	36	Singular	NA	5	i.p.	“Adult” (345g)	Same day	28	20 mins.	Increased total social interaction and general exploration; decreased anogenital sniffing and rearing.	NA	NA
van Nieuwenhuijzen 2010 [212]	Rat	Males	NA	24	Chronic	Daily over 10 days	5	i.p.	220-300g	220-300g	21	Nil	Decreased general-investigation time.	NA	NA
Wallinga 2009 [80]	Rat	Males	NA	21	Chronic	Thrice, 3-hour intervals	6	i.p.	425g	133	21	1 day	Low-aggressive: 4-month-old intruder caused increased aggressiveness.	NA	NA