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. 2021 Jun 23;19(7):1090–1100. doi: 10.2174/1570159X18666201029150937

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© 2021 Bentham Science Publishers

This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

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Fig. (2) — The pathophysiological factors involved in abnormal CGRP release in the trigeminovascular system during migraine. Pro-inflammatory cytokines and NO can enhance CGRP expression during migraine. Their secretion may result from (1) the local inflammation at the end of C-fiber and (2) satellite glial cells within TG. (3) 5-HT signaling and (4) melatonin signaling can down-regulate CGRP expression. (A higher resolution / colour version of this figure is available in the electronic copy of the article).