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. 2021 Dec 20;19:441. doi: 10.1186/s12951-021-01200-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — (A) CLSM images of HepG2 cells incubated with SS and C6 NPs at 37 °C for 4 h. Scale bars, 20 μm. In vitro cytotoxicity against (B) HepG2 cells and (C) HL-7702 cells of free DHA and SS NPs at different concentrations after incubation for 48 h. (D) Flow cytometry data for apoptosis in HepG2 cells treated with different concentrations of SS NPs