Table 2.

Trial construct 1—symptomatic trial. Power to detect an expected 2.60-point difference in ADAS-cog change in the planned sample (n = 360)

Trial modification	Linear mixed effects model: categorical time	Linear mixed effects model: continuous time	Student’s t test	Original t test (for reference)
Scenario 1	.51	.35	.33	.80
Scenario 2	.89	.69	.72	.80
Scenario 3	.98	.85	.90	.80