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. 2021 Dec 20;19:432. doi: 10.1186/s12951-021-01186-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Cellular targeting performance of HPDC NPs. A CLSM images of DiI-labeled PDC NPs co-incubated with FITC-labeled anti-HIF 1α antibody for 2 h. NPs bound with anti-HIF 1α antibody exhibited yellow fluorescence in the merged images (magnification in the small images was 1800 ×). B Flow cytometry analysis of DiI-labeled PDC NPs and FITC labeled excess antibody after incubation for 2 h through covalent coupling reaction. C CLSM analysis (Scale bars were 100 and 20 μm, respectively) and D flow cytometry analysis of cellular endocytosis of DiI-labeled HPDC NPs (100 ppm) in walker256 tumor cells after varied incubation durations