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. 2021 Dec 20;19:432. doi: 10.1186/s12951-021-01186-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — In vivo biosafety evaluation and anatomical location of HPDC NPs. A H&E stained images acquired from the major organs (heart, liver, spleen, lung, and kidney) of female rats after the subcutaneous injection with PBS (control) and HPDC NPs (1, 7, and 14 days) (Scale bars: 200 μm). B Routine blood parameters and biochemical indexes examination of the female rats after subcutaneous injection with PBS (control) and HPDC NPs for 1, 7, and 14 days feeding, including white blood cell (WBC), red blood cell (RBC), platelet (PLT), hemoglobin (HGB), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), blood urea nitrogen (BUN), creatine kinase (CK), and creatinine (CR) (n = 3 per group). C Appearance and H&E stained images of the skin 2 h after the subcutaneous injection of PBS, HPDC NPs and DOC (Scale bars: 50 μm). D Anatomical location of lymph nodes after the subcutaneous injection of HPDC NPs