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. 2021 Dec 20;18:31. doi: 10.1186/s12950-021-00296-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — LncRNA TUG1 was involved in sepsis-induced liver injury and mitochondrial dysfunction improvement triggered by Rg3. (A-D) C57BL/6 mice were randomly divided into sham group, CLP group, and CLP + Rg3 group (n = 6). (A) H&E staining for liver injury in mouse liver tissues. (B-C) Western blot assay for the protein levels of complex I, complex II, and OPA1 in mouse liver tissues. (D) qRT–PCR assay for the relative expression of TUG1 in liver tissues. (E-H) Human primary hepatocytes were treated with LPS or LPS + Rg3. (E) CCK-8 assay for the cell viability of treated cells. (F-G) Western blot assay for the protein levels of complex I, complex II, and OPA1 in treated cells. (H) qRT–PCR assay for the relative expression of TUG1 in treated cells. n = 3 independent experiments. Differences between groups were compared using the Mann–Whitney U test or Kruskal–Wallis-Wallis test. *P < 0.05, **P < 0.01