Table 1.

Inclusion criteria and transdiagnostic sample characteristics based on a modified version of the clinical staging model by Hartmann et al [16].

Stage and criteria					Measure
1a (distressed individuals)
			Psychological distress (K10a score ≥20) but not fulfilling criteria of stage 1b or 2		K10
1b (CHARMSb)
	Psychosis trait vulnerability
		First degree relative with psychosis and SOFASc < 50 in the last 12 months or Or SOFAS 30% below the past level		Family risk SOFAS
	Psychosis trait vulnerability
		Schizotypal personality and SOFAS <50 in the last 12 months or Or SOFAS 30% below the past level		SCID IId SOFAS
	Bipolar trait vulnerability
		Depressed mood or diminished interest or pleasure for at least 1 week as well as two additional criteria of depression: weight loss, sleep disorder, psychomotor disturbances, loss of energy, feelings of worthlessness or guilt, diminished ability to think or concentrate or indecisiveness, suicidality And mood swings for at least 6 months in the lifetime (not symptom-free for a longer period than 2 months consecutively) and at least three symptoms: decreased need for sleep, increased energy, inflated self-esteem or grandiosity, increase in goal-directed activity, restlessness, increased talkativeness, unusual ideas, risky behavior, inappropriate humor (does not have to equal loss of function!) Or first degree relative with bipolar disorder		SCID-5e Family risk
	Attenuated psychotic symptoms
		CAARMSf global rating score of 3-6 and frequency of 3-6 on the subscales: unusual thought content, nonbizarre ideas, perceptual abnormalities, disorganized speech Or global rating score of 6 and frequency of 3 on the subscales: unusual thought content, nonbizarre ideas, perceptual abnormalities, disorganized speech		CAARMS
	Attenuated hypomanic symptoms
		Elevated, expansive or unusually irritable mood on at least 2 consecutive days And 2 (or in case of only irritable mood 3) additional criteria: inflated self-esteem or grandiosity, decreased need for sleep, increased talkativeness, flight of ideas or subjective experience that thoughts are racing, distractibility, increase in goal-directed activity or psychomotor agitation, unusual ideas, increased involvement in activities that are pleasurable in short time but have a high potential for long-term damage For a duration of 3 days maximum if 3 or more (or in case of only irritable mood 4 or more) additional criteria are met and there are functional disturbances or others notice the mood or functional disturbances For a duration of 6 days maximum if 3 or more (or in case of only irritable mood 4 or more) additional criteria are met or there are functional disturbances or others notice the mood or functional disturbances Exclusion: hospitalization, severe impairment in social or professional functioning, no psychotic elements		CAARMS
	Moderate (attenuated) depression
		Mild or moderate depression (current or lifetime), that is, at least 1 cardinal symptom, 5 additional symptoms And HAM-Dg>17 (cutoff)		SCID-5 HAM-D
	BLIPSh
		Global rating of 6 on the subscales: unusual thought content or nonbizarre ideas Or global rating of 5 or 6 on the subscale perceptual abnormalities And/or global rating of 6 on the subscale disorganized speech present for less than a week And frequency of 4-6 on all above mentioned scales		CAARMS
	Anxiety
		Mild or moderate panic disorder /agoraphobia (current or lifetime) Or not fully meeting criteria for GADi, that is, symptoms for less than 6 months or less than four symptoms met Or mild or moderate social phobia (current or lifetime) And HAM-Aj>9 (cutoff)		SCID-5 HAM-A
2 (first treated episode)
	Psychosis				CAARMS
	Severe major depression (current or lifetime)				SCID-5
	Mania or hypomania				SCID-5
	Severe anxiety disorder (current or lifetime); eg, agoraphobia, GAD				SCID-5

^aK10: Kessler Distress Scale [81].

^bCHARMS: Clinical High At-Risk Mental State.

^cSOFAS: Social and Occupational Functioning Assessment Scale [84].

^dSCID II: Structured Clinical Interview for DSM-IV Axis II Personality Disorders,

^eSCID-5: Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) [79].

^fCAARMS: Comprehensive Assessment of At-Risk Mental State [80].

^gHAM-D: Hamilton Depression Rating Scale [85].

^hBLIPS: brief limited intermittent psychotic symptoms.

ⁱGAD: Generalized Anxiety Disorder.

^jHAM-A: Hamilton Anxiety Rating Scale [86].