Table I.
Characterization and Batch-To-Batch Variability of GT DcNPs
| Batch | Size (nm)a | AE%b |
[Drug Conc] (mg/mL) |
||
|---|---|---|---|---|---|
| PTX | GEM | PTX | GEM | ||
| 1 | 49.2 ± 35 | 95 | 7 | 1 | 13.9 |
| 2 | 59.9 ± 44 | 97 | 9 | 1.2 | 13.9 |
| 3 | 69.7 ± 47 | 97 | 10 | 1.3 | 15.3 |
| 4 | 68.7 ± 46 | 97 | 10 | 1.1 | 14.5 |
| 5 | 48.5 ± 30 | 92 | 8 | 0.7 | 14 |
| Average | 59.2 | 96 | 9 | 1.1 | 14.3 |
| S.D | 9.2 | 2 | 1 | 0.2 | 0.5 |
a
Mean particle diameter was determined by photon correlation spectroscopy and presented as the mean ± standard deviation
b
Association efficiency of gemcitabine (Gem) and paclitaxel (PTX) was determined by dialysis under sink conditions as described in Materials and Methods