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. 2021 Dec 20;40:397. doi: 10.1186/s13046-021-02210-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Specific sequence features characterize NEK2 regulated cassette exons. A Boxplots showing comparison between NEK2-regulated cassette exons (si-NEK2 reg.cassette, n = 139) and other not-regulated cassette exons (ref. cassette, n = 11,051) or constitutive exon (ref. constitutive, n = 22,480) for strength of their acceptor (right) and donor (left) splice-site. B Boxplots showing comparison between indicated groups of cassette exons for the length (left panel) and score of their polypyrimidine tracks (right panel). C Boxplot showing distance of the branchpoint from the acceptor splice-site of the indicated groups of cassette exons. D Boxplots showing the GC content of indicated groups of cassette exons (left panel) and of their flanking intronic sequences (middle and right panel). Whiskers indicate 1.5 interquartile range and highlighted circle mean values (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001;ns = not significant, t-test)