Table 1.
Characteristics of the Patients at Baseline, According to Treatment Assignment
| Characteristic* | Treatment assignment |
|||
|---|---|---|---|---|
| Emtricitabine/Tenofovir | Colchicine+Rosuvastatin | Emtricitabine/ Tenofovir + Colchicine + Rosuvastatin | Standard of Care | |
| (N=160) | (N=153) | (N=159) | (N=161) | |
| Female sex — no. (%) | 60 (37.5) | 50 (32.7) | 47 (29.6) | 48 (29.8) |
| Age | ||||
| Mean age±SD — yr | 56.6±13.1 | 56.1±13.2 | 53.6±12.6 | 55.3±12.3 |
| Over 60 years — no. (%) | 66 (41.2) | 62 (40.5) | 47 (29.6) | 61 (37.9) |
| Urban Residency — no. (%) | 152 (96.8) | 149 (98.0) | 152 (96.8) | 156 (96.9) |
| Marital status — no. (%) | ||||
| Single | 25 (16.2) | 21 (13.9) | 29 (18.5) | 24 (15.4) |
| Married | 91 (59.1) | 99 (65.6) | 94 (59.9) | 94 (60.3) |
| Other | 38 (24.7) | 31 (20.5) | 34 (21.7) | 38 (24.4) |
| Schooling — no. (%) | ||||
| Primary or less | 13 (8.6) | 17 (11.9) | 13 (8.6) | 20 (13.2) |
| Secondary or Middle | 54 (35.5) | 52 (36.4) | 48 (31.6) | 47 (30.9) |
| Technical and technological | 22 (14.5) | 19 (13.3) | 18 (11.8) | 17 (11.2) |
| Professional and specialized | 63 (41.4) | 55 (38.5) | 73 (48.0) | 68 (44.7) |
| Social stratification (%)† | ||||
| Medium-Low | 110 (71.0) | 110 (74.3) | 102 (68.0) | 102 (65.8) |
| Medium-High | 45 (29.0) | 38 (25.7) | 48 (32.0) | 53 (34.2) |
| Previous coexisting conditions — no. (%) | ||||
| Smoking | 24 (15.3) | 21 (14.2) | 26 (16.9) | 33 (20.9) |
| Alcoholism | 7 (4.5) | 3 (2.0) | 4 (2.6) | 7 (4.5) |
| Cardiovascular disease | 9 (5.6) | 4 (2.6) | 2 (1.3) | 2 (1.2) |
| Diabetes mellitus 1-2 | 21 (13.1) | 24 (15.7) | 19 (11.9) | 12 (7.5) |
| Chronic respiratory disease | 9 (5.6) | 6 (3.9) | 5 (3.1) | 8 (5.0) |
| Arterial hypertension | 46 (28.7) | 51 (33.3) | 50 (31.4) | 29 (18.0) |
| Cancer | 9 (5.6) | 8 (5.2) | 6 (3.8) | 5 (3.1) |
| Obesity | 58 (38.2) | 48 (34.0) | 58 (39.2) | 45 (30.2) |
| Glomerular Filtration Rate — mean±SD | 88.3±19.4 | 91.7±17.4 | 91.4±19.6 | 92.8±16.6 |
| Length of stay in previous month — no. (%) | 0 (0.0) | 3 (2.0) | 3 (1.9) | 7 (4.4) |
| Charlson CCI — mean±SD | 0.3±0.7 | 0.4±0.9 | 0.3±0.7 | 0.2±0.6 |
| NEWS2 Classification — no. (%) | ||||
| Low | 66 (41.2) | 59 (38.6) | 69 (43.7) | 74 (46.0) |
| Medium | 55 (34.4) | 54 (35.3) | 55 (34.8) | 51 (31.7) |
| High | 39 (24.4) | 40 (26.1) | 34 (21.5) | 36 (22.4) |
| Epidemiologic contact history — no. (%) | ||||
| Known contact history | 58 (36.2) | 53 (34.6) | 63 (39.6) | 66 (41.0) |
| Community contact | 55 (94.8) | 50 (94.3) | 57 (90.5) | 60 (90.9) |
| Transportation contact | 0 (0.0) | 1 (1.9) | 0 (0.0) | 1 (1.5) |
| Healthcare staff | 3 (5.2) | 2 (3.8) | 6 (9.5) | 5 (7.6) |
| Service/Unit of current stay — no. (%) | ||||
| General ward | 112 (70.0) | 109 (71.2) | 110 (69.2) | 114 (70.8) |
| ICU-Intensive | 44 (27.5) | 37 (24.2) | 44 (27.7) | 44 (27.3) |
| ICU-Step-down | 4 (2.5) | 7 (4.6) | 5 (3.1) | 3 (1.9) |
| Pneumonia diagnosis — no. (%) | ||||
| Mild | 11 (6.9) | 12 (7.8) | 14 (8.8) | 8 (5.0) |
| Moderate | 109 (68.1) | 101 (66.0) | 102 (64.2) | 113 (70.2) |
| Severe | 40 (25.0) | 40 (26.1) | 43 (27.0) | 40 (24.8) |
| Median of days since onset of symptoms (Q1-Q3) | 9 (7-12) | 10 (6-12) | 10 (7-12) | 10 (7-12) |
| Median of days since admission (Q1-Q3) | 2 (1-3) | 2 (1-3) | 2 (1-3) | 2 (1-3) |
| Sepsis — no. (%) | 27 (65.9) | 24 (60.0) | 29 (67.4) | 28 (70.0) |
| Septic shock — no. (%) | 9 (22.5) | 8 (20.0) | 9 (20.9) | 10 (25.0) |
| ARDS — no. (%) | 39 (97.5) | 39 (97.5) | 43 (100.0) | 39 (97.5) |
| ARDS classification — no. (%) | ||||
| Mild | 0 (0.0) | 1 (2.6) | 0 (0.0) | 1 (2.6) |
| Moderate | 19 (48.7) | 18 (46.2) | 14 (32.6) | 13 (33.3) |
| Severe | 20 (51.3) | 20 (51.3) | 29 (67.4) | 25 (64.1) |
| Oxygen delivery method — no. (%) | ||||
| Non-invasive support | 100 (62.5) | 103 (67.3) | 107 (67.3) | 108 (67.1) |
| High-flow cannula | 16 (10.0) | 12 (7.8) | 13 (8.2) | 16 (9.9) |
| Mechanical ventilation | 14 (8.8) | 12 (7.8) | 12 (7.5) | 11 (6.8) |
| No oxygen | 30 (18.8) | 26 (17.0) | 27 (17.0) | 26 (16.1) |
Plus–minus values are means ±SD, ICU intensive care unit, ARDS Acute Respiratory Distress Syndrome, SD Standard Deviation, and Q1-Q3 25th percentile and 75th percentile.
Social stratification is a government classification that groups areas of residential property where the study subjects live. Under this classification, Medium-Low corresponds to subject who benefit from utility subsidies and Medium-High are subjects who either do not receive subsidies and do not have to pay contributions or must pay a premium on the cost of utilities. DANE, La estratificación socioeconómica en el régimen de los servicios públicos domiciliarios, retrieved on June 16, 2021 at https://www.dane.gov.co/files/geoestadistica/Estratificacion_en_SPD.pdf