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. Author manuscript; available in PMC: 2021 Dec 20.
Published in final edited form as: Nat Med. 2021 Apr 29;27(5):871–881. doi: 10.1038/s41591-021-01309-6

Figure S6.

Figure S6

SuStaIn creates nearly identical subtypes when initialized with different parameters (Table S5) see Methods: Replication Analysis). SuStaIn was rerun allowing a data-driven methodology to determine the number and value of z-score waypoints for each ROI. a) Qualitative contrasts of each subtype as defined using the original (Orig) parameters and the new data-driven (DD) parameters, where maps show regions significantly different between one subtype and all others (excluding S0) within the cohort (after FDR correction). b) Confusion matrix comparing subtypes identified in the original (orig) sample (y-axis), and subtypes separately identified in the data-driven parameter replication sample (x-axis). Values represent spatial correlation between average regional tau for each subtype. Values along the diagonal indicates similarity between the same subtype across both parameter sets.