Figure S9.

Lateralization across disease progression as measured with SuStaIn stage. a) Tau lateralization was measured as the mean left to right ratio of tau Z scores for all ten tau features. Higher positive numbers represent greater left hemisphere tau lateralization, whereas lower negative numbers represent greater right hemisphere lateralization. The progression of laterality over SuStaIn stage was visualized for each subtype. Lateralization generally increased with increasing SuStaIn stage. In some subtypes (particularly S2 and S3), strong lateralization was seen in both hemispheres at later stages. b) The absolute (i.e. agnostic to hemisphere) lateralization (i.e. tau asymmetry) was visualized against SuStaIn stage, indicating a general increase in lateralization with more severe tau expression. c) A three-way relationship between age, SuStaIn stage and absolute lateralization is visualized, indicating these relationships covary but are independent of one another.