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. Author manuscript; available in PMC: 2021 Dec 20.
Published in final edited form as: Nat Med. 2021 Apr 29;27(5):871–881. doi: 10.1038/s41591-021-01309-6

Figure 2.

Figure 2

Subtype stability: AD spatiotemporal subtypes replicate in another cohort using a different PET tracer. A) For both the discovery (Orig) and replication (Repl) cohorts, maps showing regions significantly different between one subtype and all others (excluding S0) within the cohort (after FDR correction). Similar spatial patterns were observed, except for a reversed pattern in S4. B) Confusion matrix comparing subtypes identified in the original (discovery) sample (y-axis), and subtypes separately identified in the replication sample (x-axis). Values represent spatial correlation between average regional tau for each subtype. Values along the diagonal indicates similarity between the same subtype across both cohorts.