Figure 5.

A theoretical model summarizing variation in the spread of tau pathology in AD. Tau pathology varies along an axis of severity (vertical in the diagram), which is inversely associated with onset age. In addition, tau varies along a spatiotempral dimension (horizontal plane in the diagram), such that an individual can be described by their fit along one of at least four trajectories. Text indicates clinical characteristics of each subtypes. Emboldened text reflects robust differences between subtypes, while normal text reflects less-robust characteristics that differentiate subtypes from tau-negative individuals